Lifelong Learning Programme

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Title of the Experience
Levels of organization of the protein molecule
Name of the teacher
Nevenka Kostova
Country where it took place
School typology
High Secondary School
Thematic Area
Experience typology
Teaching in class
Type of contact
Description of the Experience
Sheet of paper is folded into a fan. On the composed thin sides are written arbitrary functional groups of protein molecules. In the inner parts of the so formed angles of the fan are also written functional groups that are close to each other when the sheet unfolds. Unfolded sheet represents the primary structure of the protein.
The closely located functional groups form hydrogen links and cause the folding of the polypeptide chain in the space.
At the beginning the sheet is unfolded (primary structure), closest functional groups form hydrogen links. This causes the folding of the polypeptide chain (secondary structure) - the sheet is folded into a fan. In this case the functional groups at the edges of the sheet, which at the beginning were remote, now converge and this leads to the formation of new hydrogen links between them, which causes a further folding of the protein molecule in the space (tertiary structure) - the sheet is crumpled with hands to form a ball, which corresponds to the globule.
For clarification of the quaternary structure of the proteins it is used one more sheet or more (or more) and it is made of a larger ball from all sheets, where each sheet is a single polypeptide chain. In the quaternary structure of proteins two or more polypeptide chains connect through weak links.

Comments on this Teachers Experience

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Date: 2014.10.29

Posted by Lucretia Moruzi (Romania)

Very creative indeed! This technique will help students visualize the issue and they will also be challenged by the creative way it was introduced to them. Memorable!


Dissemination Seminar in Florence

31 October 2015 The seminar has been held in ITIS “A. Meucci” one of the schools involved within Goerudio project activities. Its main aim was to promote the results of the project toward a broad sample of stakeholders even overcrossing the number of people directly involved in the production of project outcomes. This purpose has been totally achieved especially thanks to the participation of students and teachers coming from different schools or from other classes instead of those ones directly involved within the project activities.